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Neurons that co-label with various anatomical markers for Alzheimer’s disease (AD) are recognized in the temporal lobe. We performed the present study to examine the genesis and histopathology of neurons that show significant AD-consistent pathology. Immunohistochemistry was performed using monoclonal antibody R12 to label cells that show a significant degree of AD-consistent pathology, such as neuritic plaques, glial inclusions, neurofibrillary tangles, and dystrophic neurites. The object of this study was to determine the best anatomical site for neostriatal lesions to be introduced in animal models of AD. The object of the study is to elucidate the morphological and histological characteristics of AD-consistent neurons, and to determine the best anatomical site to introduce lesions of the neostriatum to induce the neurodegenerative pathology in the hippocampus and the entorhinal cortex. The result of the study is that AD-consistent neurons are located in the temporo-ammonic and entorhinal cortical areas, but not in the dentate gyrus